Founder & President
30+ years leading discovery at Merck resulting in $80B+ in revenue from development of Singulair®, Vioxx®, Arcoxia®, Previcox®, Tredaptive® and Odanacatib. Recipient of Heroes of Chemistry award and two time recipient of Prix Galien.
Founder and former CEO of Datapoint Diagnostics, and co-founder of C7bio. Prior he ran business development for Intelescope, an Israeli agritech company. Jon started out in capital markets at Perimeter (portfolio of Goldman Sachs) where he created the first depth-of-book distressed debt electronic trading platform.
Chief Development Officer
Dr. Tam has 20 years of industrial experience in nonclinical and clinical drug development. Pat trained as a toxicologist and has expertise across early-phase drug development, pharmacology, bioanalytical method development and Phase I-II clinical program development and operations.
Linda's background is in accounting. She supports Mesentech in establishing new internal processes, supporting ongoing operations and financial tracking.
Gang Chen, PhD
Dr. Chen has over 20 years of experience in the biotech industry and played instrumental roles in two public companies (AnorMED and Cardiome). He has extensive experience in medicinal chemistry, process development, and analytical chemistry. He is the joint inventor of nine patents and co-author of 30 peer-reviewed journal articles.
Medicinal Chemist with four years for Postdoctoral research experience on the development of bone targetting conjugates. Previously worked on development of drug-like small molecules as amyloid-beta fibrillation inhibitors for Alzheimer's Disease.
David C. Dvorak
David served as President and Chief Executive Officer of Zimmer Biomet (NYSE and SIX: ZBH) from 2007 to 2017. During his 16-year tenure with Zimmer Biomet revenues and capitalization grew by 500% to $7.7 billion, and 300% to $26 billion respectively.
Jay Mohr BA, MBA
Partner emeritus of Locust Walk Partners, Founding CEO and Director for Gloucester Pharmaceuticals (acquired by Celgene for $640M). Currently serves as Director of the T1D Exchange, a nonprofit organization accelerating therapies for type 1 diabetes.
Dr. Samuel Wu MD, PhD
Previously managing director of MedImmune (AstraZeneca) Ventures, principal at SV Life Sciences. Prior to his VC career, Sam was an Engagement Manager with McKinsey and Company. Sam obtained an M.D. Ph.D. from Stanford University School of Medicine and an S.B. magna cum laude from Harvard University.
Barbara Yanni currently serves as an independent director of two public clinical-stage biopharmaceutical companies: Trevena (TRVN) and Vaccinex (VCNX). She is also a member of the Board of Supervisory Directors of Pharming Group NV and former director of Akcea (AKCA), Abionyx (ABNX) and Symic Bio.
David Karpf, MD
Dr. Karpf is responsible for 12 INDs and 6 NDAs/WMAs. In particular, he led the phase 3 for Fosamax (Alendronate) at Merck. Thereafter, he was ran the bone area for Roche where he got Boniva (Ibrandonate) approved. Lastly, he led the clinical development of Transcon GH at Ascendis.
Director of Metabolic Bone Diseases and Osteoporosis; formerly Chief of the Bone Tumor Service (osteogenic sarcoma, Ewing’s sarcoma) at Memorial Sloan Kettering Cancer Center.
Roland Baron DDS PhD
Prior to joining at MGH, Baron was professor of orthopedics and cell biology at Yale University School of Medicine and editor-in-chief of the Journal of the International Bone and Mineral Society. Formerly head of bone diseases at Hoechst Marion Roussel (Aventis).
Leading foundational research on mechanisms regulating the development, maintenance and regeneration of the skeleton. Professor in the Dept. of Cellular and Physiological Sciences and the Biomedical Research Centre, UBC.
Peter K. S. Siegl, Ph.D.
Practical experience advancing candidates into clinical development gained over 27 year tenure at Merck Research Labs, holding global responsibilities in discovery, development and portfolio management.
Dr. Michael Kelly
Kelly brings 25 years experience in drug discovery and development previously serving as president and U.S. site head of Renovis and senior positions at Amgen, Wyeth (Pfizer) and Wellcome (GSK).